A Blood Pressure Medication Could Help With Attention and Behavioral Problems

A recent study suggests that amlodipine, a commonly used blood pressure medication, could be effective in reducing symptoms associated with Attention Deficit Hyperactivity Disorder (ADHD). This finding opens the possibility of repurposing this drug for managing neuropsychiatric disorders.

Amlodipine and Its Role in ADHD

Amlodipine is a calcium channel blocker primarily used to lower blood pressure by relaxing blood vessels. However, recent research has explored its impact on the central nervous system.

A study published in Neuropsychopharmacology evaluated five potential medications in animal models with ADHD-like symptoms. Of these, only amlodipine significantly reduced hyperactivity. 

To confirm these findings, researchers conducted additional tests in zebrafish, a relevant model since they share about 70% of their genes with humans. The results indicated that amlodipine not only reduced hyperactivity but also impulsivity, two core symptoms of ADHD. Additionally, researchers found that amlodipine can cross the blood-brain barrier, allowing it to directly influence brain function.

Proposed Mechanism of Action

ADHD has been linked to genetic variations in L-type calcium channel subunits. Amlodipine, by blocking these channels, may modulate neuronal activity, thereby reducing ADHD symptoms. This suggests a novel therapeutic pathway that differs from traditional stimulant-based treatments.

Potential Benefits and Considerations

Repurposing amlodipine for ADHD treatment presents several advantages:

• Known Safety Profile: Since amlodipine is a widely used hypertension drug, its side effects and contraindications are well-documented.
• Accessibility: Amlodipine is affordable and widely available, making it a viable option for different healthcare settings.

However, potential side effects must be carefully considered. While amlodipine is generally well-tolerated, it can cause dizziness, drowsiness, and, in rare cases, severe hypotension. Additionally, its interactions with other medications must be carefully evaluated.

Conclusion

Recent findings on amlodipine offer a promising perspective for ADHD treatment. However, clinical trials in humans are required to confirm its effectiveness and safety in this new context. The possibility of repurposing an existing medication could accelerate the availability of alternative treatments for individuals with ADHD.