Researchers at City of Hope have discovered that consuming white mushroom supplements can reduce myeloid-derived suppressor cells (MDSCs), which are associated with the development and progression of prostate cancer. 

Myeloid-Derived Suppressor Cells (MDSCs):

MDSCs are a heterogeneous population of immature myeloid cells with immunosuppressive properties.

These cells inhibit antitumor immune responses, facilitating the growth and spread of cancer cells.

In prostate cancer, MDSCs accumulate in the tumor microenvironment, promoting disease progression. 

Effect of White Mushrooms on MDSCs:

The City of Hope study analyzed preclinical and preliminary human data, finding that white mushroom supplements reduce MDSC levels.

This reduction enhances immune response by lowering MDSC-mediated immunosuppression, boosting the activity of antitumor T cells and natural killer cells. 

Implications for Prostate Cancer:

Reducing MDSCs through white mushroom consumption suggests a complementary strategy for preventing and treating prostate cancer.

By decreasing immunosuppression in the tumor microenvironment, the immune system's ability to fight cancer cells is enhanced, potentially delaying or preventing disease progression. 

Final Considerations:

Although the findings are promising, consulting healthcare professionals before starting any supplementation is essential.

Research is ongoing, and while consuming fresh mushrooms may be beneficial, self-medicating with unapproved supplements could pose risks.